Diabetes Articles
  • Sign Up
FacebookTwitterDiggStumbleuponGoogle BookmarksRedditLinkedinPinterest

Analysis of pathogenesis of juvenile new onset diabetes

Results  Among the total of 900 subjects analyzed, 145(16.1%) patients were negative for all 5 anti‐islet antibodies, and a tendency for a significant increase in autoantibody negativity was seen from very young children to adolescents and young adults: 10.2% (38/372) among children under age of 10 years, 14.2% (46/325) between 10 and 14 years, and 30.1% (61/203) above 14 years (p<0.001). IA‐2 autoantibodies had the highest prevalence among the children with type 1A diabetes while prevalence of GAD65 autoantibodies increased with age and were dominant in adults with diabetes. In contrast, the prevalence of mIAA was inversely correlated with age. At diagnosis, the antibody negative patients had a higher body mass index (BMI) than the antibody positive subjects (23.9 vs. 19.2; p< 0.001). Among antibody positive patients, 27.2% (116/426) had heterozygous allelic combination DR3‐DQ2/DR4‐DQ8, versus only 9.9% (12/121) among antibody negative subjects (p<0.01). Also, the antibody negative subjects had a much higher frequency of the DQ6.2 molecule than the antibody positive subjects (12.5% vs. 1.6%; p<0.01).

Read Full Article

Find out if you qualify for discount Diabetic testing supplies, free offers or other running discounts at this time.


  1. First Name*
    Enter first name
  2. Last Name*
    Enter last name
  3. Phone*
    Enter valid US phone number
  4. E-mail*
    Enter email address



By submitting this form I authorize to be contacted by telephone. Please be assured that we value and protect your privacy. Co-Pays and Deductibles may apply.

About The Diabetes Network

The Diabetes Network was developed with the idea that people living with diabetes needed a central place to go for resources as well as get ideas, suggestions and encouragement. We have put a lot of effort into this website to make it easy and fun to navigate as well as informative so that you can have a voice when it comes to managing your diabetes. Please let us know how we can improve this website to better suit your needs.

More about our Mission

We're on a mission to make the healthcare community more technologically advanced than ever before. This website adapts to fit your tablet, iPad®, iPhone®, Android® or other smartphone. Just one of the ways we are working to make life easier for those living with Diabetes. Learn More...