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No Virginia Lowering Blood Sugar Does NOT Kill People with Type 2

Yet another PR release misrepresenting the latest findings of the ACCORD study is polluting the health news this week, and as a result tens of thousands of people with Type 2 diabetes will be given bad advice by their family doctors that will cause them to suffer unnecessary complications.

I try to stay objective, but sometimes the sheer amount of poorly summarized research that is even more poorly reported in the media makes me want to weep.

I have written at length about the ACCORD study, which is the study doctors cite when they tell patients, many controlling blood sugar with diet, that it is dangerous to lower their A1c below 7%. You can read those posts here:

ACCORD REDUX: It's the High Blood Sugars Stupid

ACCORD Redux: Low A1c Does Not Raise Risk of Death

When the Doc Says Lowering Your A1c is Dangerous

If your doctor tells you that lowering your A1c is dangerous, remind him or her of what the ACCORD study actually found, which was this: People who attempted to lower their A1c to 6.5% using a combination Avandia, insulin, and a high carb diet had a higher risk of death only when they did not actually achieve a lowered A1c..

The people who DID manage to lower their A1cs in the ACCORD "intensive control" group did fine.

Today's study is NOT news. It is an extension of the same poorly designed ACCORD study whose results were deconstructed and debunked--but not until a lot of family doctors got the message that they must stop their patients from lowering their A1cs below 7%--even if they did it with diet alone.

What this latest publication from the ACCORD group is, is a look at the longer term outcomes in the groups involved in the original study. You can read the very uninformative abstract here:

Long-Term Effects of Intensive Glucose Lowering on Cardiovascular Outcomes The ACCORD Study Group. N Engl J Med 2011; 364:818-828March 3, 2011

There is nothing in this study that contradicts the finding that the people in the "intensive control" group who did poorly did poorly because their A1cs dropped.

It is when you look at the news story as dumbed down for the TV audience that you see what a tragedy it is that the ACCORD study group continues to publish these studies without making it clear what they really show.

For example, when I scan Google News I see this headline: "New results from a large government-run trial confirm that very aggressive treatment to lower blood sugar is associated with an increased risk of death in people with type 2 at high risk for heart attack and stroke." And given that doctors have been brainwashed into believing that ALL people with Type 2 diabetes are at high risk for heart attack, this translates into "Don't lower your blood sugar!" or "Low A1cs Kill!"

I have people emailing me all the time now that their doctors have lectured them about how they are risking death when they lower their A1c to 5.8 using diet alone. This is idiotic.

The real headline to describe this latest ACCORD Study should be this:

STARTING INTENSIVE DIABETES TREATMENT 20 YEARS AFTER DIAGNOSIS WILL NOT REVERSE THE DAMAGE CAUSED BY THE HIGH BLOOD SUGARS OF THE PREVIOUS DECADES. LOWER A1CS IMMEDIATELY AFTER DIAGNOSIS TO SEE EXCELLENT RESULTS.

Or perhaps:

PEOPLE WHO CANNOT LOWER THEIR A1CS USING POORLY PRESCRIBED REGIMENS INVOLVING DANGEROUS TZD DRUGS AND INSULIN PRESCRIBED WITHOUT PROPER EDUCATION DO POORLY

But let's get one thing clear: Nothing in the ACCORD study suggests that lowering A1c is harmful when it is done by cutting back on carbohydrate intake, avoiding the cardiotoxic TZD drugs Avandia and Actos that were heavily used in ACCORD, and using insulin only after being given a good explanation about how it works that allows you to adjust and tailor your doses based on what you see with your meter.

If you are not using insulin in a way that is giving you frequent hypos and are achiveing A1cs in the 5% range you will not develop the neuropathy that damages the nerves that control your heart beat or the kidney disease that damages your blood pressure, or for that matter, blindness or amputation.

But I can rant on about this as much as I want. Mostly the world ignores it. You who are reading this now and are educated and can read the detailed analysis of the ACCORD studies you can find in the blog posts linked above. But most people with Type 2 diabetes trust their doctors and will do whatever those doctors tell them. Even though your average family doctor's knowledge of diabetes is often 20 years out of date and dangerously confused. And many of those doctors will tell them that they should NEVER lower their A1c below 7% because ACCORD proved it's "dangerous."

If you know someone with diabetes who isn't the kind of person who Googles things, explain to them what this study really proved--that "lowering A1c" is only dangerous when you do it with a poorly chosen drug cocktail and then don't manage to lower your A1c.

Remind them too, that ACCORD is only one, not very well designed study, and that there is a ton of other research that shows that lowering A1c to 6.5% or below does improve health, most notably the ADVANCE study, which was larger and longer than ACCORD.

 

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