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Analysis of pathogenesis of juvenile new onset diabetes

Results  Among the total of 900 subjects analyzed, 145(16.1%) patients were negative for all 5 anti‐islet antibodies, and a tendency for a significant increase in autoantibody negativity was seen from very young children to adolescents and young adults: 10.2% (38/372) among children under age of 10 years, 14.2% (46/325) between 10 and 14 years, and 30.1% (61/203) above 14 years (p<0.001). IA‐2 autoantibodies had the highest prevalence among the children with type 1A diabetes while prevalence of GAD65 autoantibodies increased with age and were dominant in adults with diabetes. In contrast, the prevalence of mIAA was inversely correlated with age. At diagnosis, the antibody negative patients had a higher body mass index (BMI) than the antibody positive subjects (23.9 vs. 19.2; p< 0.001). Among antibody positive patients, 27.2% (116/426) had heterozygous allelic combination DR3‐DQ2/DR4‐DQ8, versus only 9.9% (12/121) among antibody negative subjects (p<0.01). Also, the antibody negative subjects had a much higher frequency of the DQ6.2 molecule than the antibody positive subjects (12.5% vs. 1.6%; p<0.01).

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Type 2 diabetes-related hospitalizations increasing

Cases of reported type 2 diabetes are increasing across the country. As these numbers rise, so too do the number of people who experience potentially serious complications.

Health officials in San Diego County recently reported that the state has seen an increase in the number of unnecessary hospitalizations for diabetes-related complications, according to the San Diego Union-Tribune. The numbers suggest that as more people develop the condition, fewer are getting the care that they need.

The report indicates that the number of hospitalizations for diabetic ketoacidosis, dehydration, coma, kidney failure, nervous system problems and appendage amputations increased by 8 percent between 1999 and 2008.

"It's certainly something the county would want to ask, why these are going up," Michael Kassis, who wrote the report for the country, told the news source. "In the long-term complications (for diabetes), the questions would be whether people have adequate access to care and if they are actually following that treatment if they do have access to care."

Nationally, the number of people hospitalized for type 1 or type 2 diabetes-related causes has been steadily increasing since the mid-1990s.

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Lowering drug co-pays may help diabetics stay healthier

Type 2 diabetes and other chronic conditions can be the most costly diseases to care for. However, a new study from a team of Florida researchers has found that lowering insurance copayments could result in lower costs for everyone.

While the findings, which were published in the journal Health Affairs, may seem counterintuitive, the researchers said that they make sense when the numbers are broken down. By lowering out-of-pocket expenses, the researchers found that individuals were more likely to take advantage of services that keep them healthy rather than only seeking care once they have become


Birth Around the World: A Tale of Two Births in Canada

Joanne is a software engineer in Ontario, Canada. Her first child was born in 2007 at Kitchener Ontario's Grand River Hospital, which sees about 4,000 births per year. She chose a midwife-attended homebirth in 2010. This post is lengthy, but it’s really two birth stories in one! It shows two contrasting styles of maternity care available in present-day Canada.

When I became pregnant with my first child in 2007, I had no reasons to distrust the latest technology and knowledge of the Western medical establishment. My family doctor referred me to an obstetrician, who are in short supply


Guest post: Candi's home waterbirth story (finally!)

A few months ago, I shared with my readers Doula'ing my nephew's gorgeous home waterbirth! with photos from her birth. My sister-in-law Candi finally typed up her birth story and asked if I would share it with all of you. Isn't she thoughtful?

“For this child I prayed; and the LORD hath given me my petition which I asked of him..." 1 Samuel 1:27

I’ve thought a lot the last 10 days (there was a little break in there, now it’s been 12 weeks) about how I am going to put his birth into words. Whenever anyone asks me how it


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