Diabetes Articles
  • Sign Up
FacebookTwitterDiggStumbleuponGoogle BookmarksRedditLinkedinPinterest

bookDiabetes articles about daily topics that affect those living with diabetes. There is a lot of information about diabetes and hopefully you find this information useful in your everyday life. Here we have compiled a list of older articles from our previous "The Diabetes Network" along with links to blogs and articles, an extended reading archive. You can use the search in the top-right menu to search for specific articles.

 

Multiple Diabetes Injections Could Yield to Injections Just 3 Times a Week

.
Excerpted from ABC NewsMarch 10, 2011

A new study, published in the Lancet, found that a longer acting form of insulin, known as degludec, is just as effective as the existing long-lasting insulin, glargine.

One injection of glargine lasts 18 to 26 hours, but study participants who used degludec had the same amount of blood sugar control as glargine while only getting injected three times a week instead of daily.

Sticks and Pricks of the Study

Participants who took degludec had lower rates of hypoglycemia.

"This would give patients the same level of control in insulin with much less chance of hypoglycemia," said Dr. Bernard Zinman, director of the Leadership Sinai Center for Diabetes and lead author of the study. "It was so long-acting that we looked at administering it less frequently, and even under those circumstances we had an excellent response with respect to lowering glucose."

Researchers enrolled 245 people aged 18 to 75 years old with type 2 diabetes onto the preliminary trial. Patients were randomly assigned to receive the three-times-a-week or the daily insulin injection.

"This was a proof-of-concept study," said Zinman. "We need to wait for much larger studies involving more patients under different circumstances to see whether this would be valuable in the clinical setting."

Dr. Gerald Bernstein, director of the Diabetes Management Program at Beth Israel Medical Center in New York, said that other "basal-like," or background, insulins, like NPH and Levemir, already are being used today.

"In my mind, there is no question that, with hundreds of millions of people with Type 2 diabetes, there will be subgroups that would benefit and respond to one of these insulins," said Bernstein.

"If this new preparation would get more people to take insulin earlier, that would be a plus," said Bernstein. "As it proves itself out, it may be of significant value in the future."

According to the American Diabetes Association, nearly 26 million people have diabetes in the United States. Type 2 diabetics often do not have indicating symptoms of the disease but sometimes they will suffer from frequent infections in the skin, gums or bladder, blurred vision, bruises that are slow to heal and tingling in the extremities.

Type 2 diabetics do not produce enough insulin or the cells ignore the insulin.

Potential Breakthrough When Lowering Hypoglycemia

Most diabetic patients who take insulin need about two shots per day to control blood sugar levels. But it is not uncommon for people to inject insulin four times a day.

"Another long-acting basal insulin that might be effective when given every three days could improve adherence and reduction in hypoglycemia, [which] is always an important goal in that hypoglycemia deters adherence with and acceptance of insulin therapy in type 2," said

While study authors warned that the insulin is not ready for clinical use, many doctors remain hopeful that the drug will cut down insulin maintenance for diabetic patients in the future.

"This is a promising advance in the management of diabetic patients, easy to take, less cumbersome, perhaps cheaper and, if indeed [it] has less hypoglycemia episodes, even better," said Dr. Albert Levy, assistant professor of medicine at Albert Einstein College of Medicine in New York. "The most common side effect of practically all insulin injections is hypoglycemia, and if this unwanted side effect is minimized it would be a major breakthrough."

Sources include
http://abcnews.go.com/Health/diabetes-study-finds-times-week-insulin-improves-glucose-levels/story?id=13097090&page=3
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)62305-7/fulltext
http://www.novonordisk.com/include/asp/exe_news_attachment.pdf?sAttachmentGUID=eb95fd24-0fdc-4f82-9d64-9dd748c78c0f
http://www.lantus.com/
http://www.lunenfeld.ca/researchers/zinman
http://www.friedmandiabetesinstitute.com/
http://www.aolhealth.com/2010/08/24/meet-diabetes-expert-dr-gerald-bernstein/
http://www.diabetes.org/
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001423/
http://www.einstein.yu.edu/home/faculty/profile.asp?id=3017
http://www.einstein.yu.edu/home/default.asp

Read Full Article

Is your Apidra dying early???? Commenting Fixed, I hope

Is your Apidra dying early???? Commenting Fixed, I hope

NOTE - blogspot decided I don't need to see any comments for some reason. I had to turn off comment moderation. Any comments on this post went into some kind of black hole, so please recomment if you said something before...

I live in upstate New York, I've tried two different pharmacies (an independent and a CVS) and I seem to run into issues with my Apidra dying about 10 days after opening a vial. It can't be my fridge as it happens even with the first vial I bring home from the pharmacy, which gets opened and set on my dresser.


This has been happening on and off since July, but it's gotten really bad since Christmas. I'm talking like 80% of the insulin I open lasts a week. Has anyone else seen this???

My last two bottles (different pharmacies, both not very effective after 6 or 7 days, and virtually dead by 10) are from lot numbers 40C413 (exp 7/2011) and 40C419 (exp 9/2011).

Anyone out there with those lot numbers, can you let me know if yours works? I suspect all the local pharmacies may get supplied from the same place....

Thanks!

Read Full Article

P90X, diabetes, and the insulin pump - a match made in...

...the brain of some delusional being!

Only kidding there.

I advocate getting exercise. When you have diabetes, it's that much more important. Go walk Fido, take a stroll with your sweetie, mow the lawn, play the wii..... :) you get the picture.

P90X is an extreme home fitness routine. If you have cable, you've seen the ads - regular people like you and I working (very) hard and getting (very) fit. I wasn't so sure about this, but I really wanted to try it. I mean, every time the infomercial came on (no matter which one, there's multiple ones!) I watched it, and wondered....

Could I not only get BACK in to shape, could I get in to the best shape of my life? The answer? Yes.

To learn more about P90X, you can go anywhere on the internet and read countless stories of staggering health transformations. Before I get in to the diabetes part, I want to share my motivation.

When my feet starting hurting (BAD) I went to see a neurologist. A nurse there is an acquaintance, and when I stepped on the scale she muttered, "I never would have guessed."

Cue total shame and anger simultaneously.

The nerve, I mean come on - really? 201. 201. 2 - 0 - 1. Is it really that BIG of a deal? Apparently so. The next day the diet changed and the cardio and weight training (re)started. A few months later, it was my birthday and my wife surprised me with P90X. That was the best gift she's ever given me, after our son Nate and our golden retriever, Bentley.

But before P90X you begin you have to take this fitness test.

P-Uuuuu-Lllll-eeeeee-aaaaaa-sssssss-eeeeee I was thinking. I am SUPER FIT (in my mind). Then I got started. It's exhaustive - vertical leap, push ups, pull ups, etc. I was ok (they give you minimums) until I had to sit down and try to touch my toes. Now, I was never a dancer, gymnast, etc. and had never at that point done yoga (just for girls, I thought); but still I really considered myself flexible. Not so much. The minimum GAP between outstretched fingers and toes is 6." My best effort? 6", and barely at that. Whew - on to the program.

Suffice to say that after day 2 I literally could not walk right for 5 days. I just wasn't used to it. But after another week or so I hit my stride, and I was addicted.

Being on the pump (or just having diabetes) and engaging in strenuous exercise can be taxing. I was going low, A LOT. So here's what I did.

Google!

I came across a professional-grade athlete with diabetes, and I emailed him, asking for his help. A day or so later I heard back, and what he told me made all the difference in the world. He recommended a book to me that I am here and now recommending to you, no matter what kind of exercising you do:

"The Diabetic Athlete's Handbook."

Yeah, diabetic is a word some of us are not crazy about, but the info in the book is incredible. It profiles athletes and their specific programs, and make suggestions for pump users, shot takers, and type-2'rs. There's something there for everyone. Back to my journey...

When I did the program (aprox 1 hr/day) I would take my pump off entirely. Prior to exercising I would reduce my insulin (bolus for eating) by 50%, and my basal rates would be decreased by 30% or more for at least 12 hours AFTER the exercise.

That did it for me, I drastically reduced my lows, and most days worked-out problem free. There were occasions I had to stop working out due to a low, and other days I had to delay a start because my level was 'normal.' If it wasn't elevated at the start, it would crash for me.

The program itself is incredible, and I found the Yoga portion to be most challenging, yet mutually rewarding upon completion.

It IS possible to do an extreme program like P90x while on the pump, or shots - it just takes more planning than normal.

The payoff is worth it, though.

Plus, now I can reach BEYOND my toes, and I am in the best shape of my life!

So get out there, get moving, and stay healthy!

Until next time, keep pumpin'...

Read Full Article

Feeling Cold, pt. 2 - effect of insulin on body temp


As you may recall, I recently started doing some data recording of my basal body temperature at waking and before bed. Through that data, it was pretty obvious that my core body temperature (CBT) is more than a bit lower than the normal 98.6 degrees (F). I have consistently run 96.5. Having established my initial baseline for my A-B-A data set test for my upcoming experiments on increasing my own CBT, I was doing some Google-research when I stumbled upon a preview of an article to be published this coming October in the medical journal, Diabetes.

The article is entitled "Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons." The objective of the research was to examine the role of the metabolic signal insulin in the control of core body temperature. The findings demonstrated that insulin can directly modulate hypothalamic neurons that regulate thermogenesis and CBT which indicated that insulin plays an important role in coupling metabolism and thermoregulation at the level of anterior hypothalamus. Since I myself don't have a subscription to the Diabetes medical journal nor feel like spending $45 to read something I probably can't understand in the first place, I'll just assume they are correct until one of you readers points me to contrary medical research.

According to a summary medical article on Medical News Today "New Link Discovered Between Core Body Temperature and Insulin," while much research has been conducted on insulin since its discovery in the 1920s, this is the first time the hormone has been connected to the fundamental process of temperature regulation:

The scientists found that when insulin was injected directly into a specific area of the brain in rodents, core body temperature rose, metabolism increased, and brown adipose (fat) tissue was activated to release heat. The research team also found that these effects were dose-dependent - up to a point, the more insulin, the more these metabolic measures rose.

"Scientists have known for many years that insulin is involved in glucose regulation in tissues outside the brain," said Scripps Research neurobiologist Manuel Sanchez-Alavez, who was first author of the new paper with Bartfai lab colleagues Iustin V. Tabarean and Olivia Osborn (now at the University of California, San Diego). "The connection to temperature regulation in the brain is new."

...

In work coordinated by Osborn to characterize these neurons and their transcriptome (all of the messenger RNA molecules in a cell, which reflect the genes being expressed), the team noticed something unexpected - a messenger RNA for an insulin receptor.

"We were surprised to find the insulin receptor," said Tabarean. "The insulin receptor is very well documented in the pancreas and in other peripheral tissues. But in the brain, it was not clear and we definitely did not know about its existence in warm-sensitive neurons."

The article goes on to explain the methodology, then draws some conclusions:

The authors note that while their new paper illuminates a key piece of the puzzle of the body's metabolic processes, it also raises many intriguing questions: How does insulin get to the brain's preoptic area - does it cross the blood-brain barrier or is it produced locally? Are diabetics, who are insensitive to insulin in peripheral tissues, still sensitive to insulin in the brain; if so, could this dichotomy be used in the development of a new therapy? Could scientists find a way to use these new insights to increase energy expenditure for the purpose of weight loss?

Unlike the rodents in the medical tests, I'm not really in much of a position to stick a syringe into my brain and inject a bit of humalog to see what happens. So, I thought I'd ask for volunteers. Just kidding!

It does, however, give me an idea for an experiment to try: determining the effect deprivation of all insulin from my system would have on my CBT. Given the above, would my CBT actually be lower if I had, say, 24 hours of no insulin whatsoever? It would be a pretty simple test to complete, perhaps at my next scheduled site change. Don't worry, I'd couple it with a complete fast as well so my blood sugar levels shouldn't rise too high... that in and of itself would be pretty interesting to know as well: what is the rising rate of one's blood sugar if nothing is ingested?

As always, please don't try this at home. I don't mind screwing up my own body processes in the name of science, but I don't want to worry that I'm messing with your own. But, if you do decide to give it a try, don't hesitate to share the data!

Read Full Article

Letter to a New Diabetic: Lowering Blood Sugar

Dear Concerned:

Welcome to the wonderful (and head scratching) world of blood sugar prediction. What works once may not work again the next time and what works for one person may not work for another. That's because reducing a high blood sugar is part science, part art and part luck.

The science is in doing the calculations. If your blood sugar is 200 and you want to lower it to be at 100, you need to know how much 1 unit of insulin will reduce your blood sugar (value of "x"). Then just take 100 / "x" to get the number of units to take. This is a fairly simple algorithm that you and your Endo (diabetic doc) can determine by fasting and doing food/insulin tests. You probably have a "basic" rule for reduction but the more you can do to make it specific to you, the more accurate and hence the better.

The art of treating a high blood sugar comes from knowing how YOUR body reacts to insulin, particularly when your blood sugar is at a higher level ( i.e., 1 unit = x reduction, but if the blood sugar is over 300, 1 unit only = 1/2 of x.) The only person that can take the time to figure that out is you. The other aspects that you have to consider include what you are doing at the time, e.g. exercising, moving, sleeping; how you are feeling at the time (as sometimes being sick = high blood sugar); and when and what you last ate and the amount of food still being digested in your system.

As for the luck in lowering your blood sugar, well, there is a dash of that as well. Sometimes you do everything right and "by the book" and then look at the numbers, scratch your head and wonder if it was all just a waste of time. It's not, of course, but it can certainly be frustrating.

Keep in touch,

Niko

Read Full Article

High Blood Glucose -3 Reasons For Morning Highs

Reason # 1
During sleep, your blood sugar may decrease as a result of the amount of insulin you took that day, and the hormones, such as glucagon, that raise blood glucose may be secreted, resulting in high blood glucose in the morning. This action is called the Somogyi effect which is named after the doctor who first described it.

Some mornings, your blood glucose may be low if it didn't get low enough to trigger hormone secretion, whereas other mornings it may be high.

If you fail to understand that the main trigger is actually too much insulin and not too little, you may increase your insulin and make the situation worse.

Before increasing insulin at bedtime, do a blood glucose test in the middle of the night. If the level is low, you're in all probability experiencing the Somogyi effect, and you should decrease, NOT increase, the amount of long-acting insulin you give inject at bedtime.

Reason # 2
Another trigger of high blood glucose may be the "dawn phenomenon" which is caused by secretion of too much growth hormone during the night. By morning, it will raise your blood glucose to high levels. If your morning blood sugar levels are consistently high, nighttime long-acting insulin usually takes care of this problem and provides more normal morning blood glucose readings.

Reason # 3
Another possible reason for a morning high, not related to either of the previously mentioned circumstances, is that the insulin used at bedtime did not work long enough to keep the blood glucose from rising overnight. Older forms of insulin such as NPH tend to fall short in this manner, whereas newer long-acting insulin like Glargine and Detemir don't.

Conclusion:
High blood glucose levels in the morning must be avoided if you want to diminish detrimental effects and improve overall glucose control. Consider the 3 reasons given here to determine which of them may be giving you a problem, then take corrective action based on your findings.

Read Full Article

Subcategories

Find out if you qualify for discount Diabetic testing supplies, free offers or other running discounts at this time.


  1. First Name*
    Enter first name
  2. Last Name*
    Enter last name
  3. Phone*
    Enter valid US phone number
  4. E-mail*
    Enter email address



By submitting this form I authorize to be contacted by telephone. Please be assured that we value and protect your privacy. Co-Pays and Deductibles may apply.

About The Diabetes Network

The Diabetes Network was developed with the idea that people living with diabetes needed a central place to go for resources as well as get ideas, suggestions and encouragement. We have put a lot of effort into this website to make it easy and fun to navigate as well as informative so that you can have a voice when it comes to managing your diabetes. Please let us know how we can improve this website to better suit your needs.

More about our Mission

We're on a mission to make the healthcare community more technologically advanced than ever before. This website adapts to fit your tablet, iPad®, iPhone®, Android® or other smartphone. Just one of the ways we are working to make life easier for those living with Diabetes. Learn More...